check it out in TIBS: http://www.cell.com/trends/cell-biology/abstract/S0962-8924%2815%2900193-2
Also, this review provides a bit more context than what is provided in the long form poem we wrote otherwise known as a nature letter. I hope the review helps! Also, Devon and Kurt are following this up and there is more to come on the subject (hopefully) shortly. The differential expression of genes with cell size is a bigger deal than the already big deal, IMHO, of cell size control.
I think this is destined to gain the thousand or so views of my reappointment talk. still, it would take a lot of globetrotting to give a seminar to 1000 people 50 at a time! I hope you like it (click here)
a very nice article from Bjorn Carey on our work analyzing the connection between growth and division in budding yeast
unexpectedly, Cln3 is not the answer...
Cell growth dilutes a cell cycle inhibitor, Whi5, while the cell cycle activator, Cln3, remains at constant concentration. When Whi5 is diluted below a critical concentration, cells enter the division cycle. Dilution of a cell cycle inhibitor is a new concept in cell biology and an elegant solution to the problem of coupling growth to division.
Read all about it here http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14908.html?WT.ec_id=NATURE-20150924&spMailingID=49614214&spUserID=NDk5Njc4MjI2OTYS1&spJobID=763182077&spReportId=NzYzMTgyMDc3S0
This paper describes one way that spatial organization within the cell can be used to provide an entirely new feature for a network motif (in this case bistable switch from mutual inhibition of Cdk and Far1 activities). We expect that compartmentalization is frequently used to create stable protein pools that can be used to enhance cellular memory of past events (in this case exposure to mating pheromone). Read it, it is good.
http://www.sciencedirect.com/science/article/pii/S0092867415001981
The third in Andreas series of papers dismantling the interface between the pheromone-induced MAPK pathway and the cell cycle (see also Doncic et al 2011, 2013 also both Mol. Cell).
Amazing work by Andreas, Oguzhan and our collaborators from Estonian and Argentina.