Cell cycle dynamics
This is a very
exciting time to study the cell cycle. In spite of our exquisite
molecular knowledge buit up over the last 3 decades, we lack a precise understanding of the regulatory
dynamics associated with cell cycle transitions. Our central aim is to link molecular circuitry to cell physiology.
Understanding the principles underlying genetic control circuits will be a central aim of biological research in the coming decade. These principles, when found, should provide a unifying framework for understanding disparate natural systems and aid in the design of robust synthetic circuits for medical and engineering purposes.
We are currently interested in understanding cell size control (in yeast and frogs) and
feedback regulation at the interface between the core cell cycle control
network and its input pathways (in yeast and human cells). We are most interested in the potential conservation of systems level features of cell cycle control.