Also, everyone needs to post preprints too, so we did that too. First time for me. Anyway, Ali, Antonia, Marius, Stanley and I wrote this manuscript describing Ali and Antonia's work using catalytically inactivate Cas9 to block transcription factor binding at specific sites. This give a quick way to check the function of particular TF binding sites. It works because guide RNAs are longer than TF binding sites so flanking sequence can be used to generate specificity.

Check it out here! https://www.biorxiv.org/content/early/2018/03/15/282681

Posted
AuthorJan Skotheim